Location: Church St and Henry St, Spartanburg Reassurance shield after the 56 split as we head out of downtown Spartanburg.   Location: Church St and Forest St, Spartanburg Cty Reassurance shield as we head out of the city of Spartanburg. Location: US-221 and Southport Rd, Spartanburg Cty As we approach SC-295, exit onto it to … Continue reading U.S. Route 221, SC-56 to SC-295